Klinik und Poliklinik für Kinder- und Jugendmedizin
 Universitätsmedizin Leipzig

Publications

Leipert J, Kässner F, Schuster S, Händel N, Körner A, Kiess W, Garten A: Resveratrol potentiates growth inhibitory effects of rapamycin in PTEN-deficient lipoma cells by suppressing p70S6 kinase activity. Nutr Cancer. 2016 Mar 4:1-8.

Garten A, Schuster S, Penke M, Gorski T, de Giorgis T, Kiess W: Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol. 2015 Sep;11(9):535-46.

Penke M, Larsen PS, Schuster S, Dall M, Jensen BA, Gorski T, Meusel A, Richter S, Vienberg SG, Treebak JT, Kiess W, Garten A: Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet. Mol Cell Endocrinol. 2015 Sep 5;412:65-72.

Wilhelm F, Kässner F, Schmid G, Kratzsch J, Laner A, Wabitsch M, Körner A, Kiess W, Garten A: Phosphatidylinositol 3-kinase (PI3K) signalling regulates insulin-like-growth factor binding protein-2 (IGFBP-2) production in human adipocytes. Growth Horm IGF Res. 2015 Jun;25(3):115-20.

Schuster S, Penke M, Gorski T, Gebhardt R, Weiss TS, Kiess W, Garten A: FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. Biochem Biophys Res Commun. 2015 Mar 6;458(2):334-40.

Schuster S, Penke M, Gorski T, Petzold-Quinque S, Damm G, Gebhardt R, Kiess W, Garten A: Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes. PLoS One. 2014 Mar 6;9(3):e91045.

Christensen MK, Erichsen KD, Olesen UH, Tjornelund J, Fristrup P, Thougaard A, Nielsen SJ, Sehested M, Jensen PB, Loza E, Kalvinsh I, Garten A, Kiess W, Bjorkling F: Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship. J Med Chem 2013, 56(22):9071-88.

Schmid GL, Kassner F, Uhlig HH, Korner A, Kratzsch J, Handel N, Zepp F, Kowalzik F, Laner A, Starke S, Wilhelm FK, Schuster S, Viehweger A, Hirsch W, Kiess W, Garten A: Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies. Pediatr Res 2013.

Sommerweiss D, Gorski T, Richter S, Garten A, Kiess W: Oleate rescues INS-1E beta-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response. Biochem Biophys Res Commun 2013, 441(4):770-6.

Spinnler R, Gorski T, Stolz K, Schuster S, Garten A, Beck-Sickinger AG, Engelse MA, Koning EJP de, Korner A, Kiess W, Maedler K: The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. PLoS ONE 2013, 8(1):e54106.

Garten A, Schuster S, Kiess W: The insulin-like growth factors in adipogenesis and obesity. Endocrinol Metab Clin North Am 2012, 41(2):283-95, v-vi.

Friebe D, Neef M, Kratzsch J, Erbs S, Dittrich K, Garten A, Petzold-Quinque S, Bluher S, Reinehr T, Stumvoll M, Bluher M, Kiess W, Korner A: Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans. Diabetologia 2011, 54(5):1200-11.

Garten A, Petzold S, Schuster S, Korner A, Kratzsch J, Kiess W: Nampt and its potential role in inflammation and type 2 diabetes. Handb Exp Pharmacol 2011, (203):147-64.

Schuster S, Hechler C, Gebauer C, Kiess W, Kratzsch J: Leptin in maternal serum and breast milk: association with infants' body weight gain in a longitudinal study over 6 months of lactation. Pediatr. Res 2011, 70(6):633-7.

Garten A, Petzold S, Barnikol-Oettler A, Korner A, Thasler WE, Kratzsch J, Kiess W, Gebhardt R: Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes. Biochem Biophys Res Commun 2010, 391(1):376-81.

Olesen UH, Petersen JG, Garten A, Kiess W, Yoshino J, Imai S, Christensen MK, Fristrup P, Thougaard AV, Bjorkling F, Jensen PB, Nielsen SJ, Sehested M: Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. BMC Cancer 2010, 10:677

Vogel R, Garten A, Klammt J, Barnikol-Oettler A, Kiess W: Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells. Arch Physiol Biochem 2010, 116(3):128-36.

Garten A, Petzold S, Korner A, Imai S, Kiess W: Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab 2009, 20(3):130-8.

Imai S, Kiess W: Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci (Landmark Ed) 2009, 14:2983-95.

Kiess W, Petzold S, Topfer M, Garten A, Bluher S, Kapellen T, Korner A, Kratzsch J: Adipocytes and adipose tissue. Best Pract Res Clin Endocrinol Metab 2008, 22(1):135-53.

Sommer G, Garten A, Petzold S, Beck-Sickinger AG, Bluher M, Stumvoll M, Fasshauer M: Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine. Clin Sci (Lond) 2008, 115(1):13-23.

Korner A, Garten A, Bluher M, Tauscher R, Kratzsch J, Kiess W: Molecular characteristics of serum visfatin and differential detection by immunoassays. J Clin Endocrinol Metab 2007, 92(12):4783-91.

Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S: Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 2007, 6(5):363-75.

Raile K, Klammt J, Garten A, Laue S, Bluher M, Kralisch S, Kloting N, Kiess W: Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells. Regul Pept 2006, 135(1-2):30-8.

Kiess W, Kratzsch J, Keller E, Schneider A, Raile K, Klammt J, Seidel B, Garten A, Schmidt H, Pfaffle R: Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene. Rev Endocr Metab Disord 2005, 6(3):183-7.

Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger AG, Kiess W: Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. Biochem Biophys Res Commun 2005, 327(2):557-64.

Korner A, Bluher S, Kapellen T, Garten A, Klammt J, Kratzsch J, Kiess W: Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges. Hormones (Athens) 2005, 4(4):189-99.

Raile K, Klammt J, Laue S, Garten A, Bluher M, Kralisch S, Kloting N, Kiess W: Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells. Diabetologia 2005, 48(9):1798-809.


 
Letzte Änderung: 09.03.2016, 10:39 Uhr
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Klinik und Poliklinik für Kinder- und Jugendmedizin