Klinik und Poliklinik für Kinder- und Jugendmedizin
 Universitätsmedizin Leipzig


Cytokines and β-cell dysfunction

Type 2 Diabetes is one of the most common metabolic diseases associated with e.g. obesity as well as heart, kidney and nerve damages. Due to insulin resistance more free fatty acids circulate in the blood stream and can be stored in other tissues such as pancreas inducing lipotoxicity. Furthermore, blood levels of cytokines are altered in the state of obesity and insulin resistance influencing the function of β-cells. However there are some more promising “new” adipokines (Omentin-1, Glypican-4), released from adipose tissue, and even hepatokines (LECT2 and HFREP1), released from the liver which could have an important role in the regulation of β-cell dysfunction as lipotoxicity, insulin secretion and lipid accumulation. Thus, the hypothesis of this project is that cytokines can offset the effects of free fatty acids on β-cell survival, insulin secretion and lipid accumulation. Artikel lesen

PTEN-associated lipomatosis

The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates the PI3K/AKT/mTOR signaling pathway. Germline mutations in PTEN cause disorders, variable in severity and progression of symptoms, summarized as PTEN hamartoma tumor syndrome (PHTS). Symptoms include cancer predisposition, immune deviations and lipomas/lipomatosis. In our lab we are etablishing lipoma derived preadipocytes and applying lipoma tissue derived from patients with PHTS. We are focusing on the origin of lipomatosis in PTEN mutation carriers and its therapeutic strategies. Artikel lesen

NAD metabolism in health and disease

The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of enzymes involved in metabolism, stress resistance and transcription. Therefore, changes in NAD metabolism have been associated with several pathologies, including metabolic disorders and cancer. NAMPT (nicotinamide phosphoribosyltransferase), the key enzyme of the NAD salvage pathway, functions as an intra- and extracellular NAD biosynthetic enzyme that is important for the regulation of NAD-dependent enzymes, such as sirtuins and poly(ADP-ribose) polymerases (PARPs). NAMPT itself or any component in NAMPT-mediated systemic NAD biosynthesis could be an effective therapeutic target/reagent for the prevention and the treatment of metabolic disorders including obesity and type 2 diabetes mellitus, inflammation, and cancer. Artikel lesen
Letzte Änderung: 16.08.2017, 09:19 Uhr
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Klinik und Poliklinik für Kinder- und Jugendmedizin