ProjectsWe are focusing on mucosal immune regulation in patients with PTEN hamartoma tumor syndrome. Due to heterozygous mutations in the PTEN gene patients develop a spectrum of symptoms including Bannayan Riley Ruvalcaba syndrome and Cowden syndrome. PTEN deficiency in humans can lead to massive mucosal lymphoid hyperplasia and autoimmunity. In close co-operation with the Uhlig group at the Oxford University we investigate the functional consequences of PTEN deficiency for the development of the mucosa associated lymphoid tissue.
We are one of numerous study centres of the international AbCD trail, focusing on the development of a diagnostic cascade in patients with clinical suspicion of celiac disease using antibody tests and avoiding biopsy in already clear cases.